Stereoisomerie en chimie organique sciences mont blanc. Vpa is extensively metabolized and forms 17 metabolites in man. This is the way i remembered it when i first came across ez notation. Le substituant terminal ayant le plus haut degre doxydation cho ou cor est toujours situe a. A monounsaturated metabolite, e2ene vpa, is at least as potent as the parent drug vpa in several animal models of epilepsy. Convert documents to beautiful publications and share them worldwide. Valproic acid vpa is a broad spectrum antiepileptic agent used widely in the treatment of absence and tonicclonic seizures. Functional interaction between local anaesthetics and calcium antagonists in guineapig myocardium. The presumed equality between ee and the earlier term op was, of course. Moreover, e2ene vpa appears to be free of two serious side effects of.
Pharmacokinetics of two monounsaturated metabolites of. Wahab diop 44 cours physique chimie terminale s pdf, chimie sur intellego sujet. Representation spatiale des molecules et chiralite. Electrophysiological studies with bupivacaine and nifedipine. Ch3 ch ch oh cho br 2r, 3r a selon fischer b selon cram c selon newman axe c2c3 avec les groupements ch3 et. Correction bac es amerique du nord 2015 maths prof en. Pdf functional interaction between local anaesthetics.
Note that morrison and mosher explicitly specified equality between optical rotation and enantiomer composition, meaning that op ee. Physique chimie term s specifique nathan sirius 2012 pdf. Publishing platform for digital magazines, interactive publications and online catalogs. It relies on the fact that the shapes of e and z isomers are the opposite of the shapes of the letters e and z. In the letter e, the horizontal strokes are all on the same side. Stereoisomerie, enantiomeres, diastereoisomeres youtube. To verify that your answers are correct, look in your textbook at the end of chapter 5.